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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T5358 | Longdaysin | ERK , Casein Kinase , CDK | |
Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM). | |||
T10479 | BAY885 | ERK | |
BAY885 is a new ERK5 inhibitor. | |||
T14360 | AX-15836 | ERK | |
AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM). | |||
TQ0005 | KO-947 | ERK | |
KO-947 is a potent and specific inhibitor of ERK1/2 kinases. | |||
T6066 | SCH772984 | ERK , MEK | |
SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak inhibitory for other 300 tested kinases. | |||
T14894 | CC-90003 | ERK | |
CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity. | |||
T5535 | ERK5-IN-2 | ERK | |
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. | |||
T5184 | ERK5-IN-1 | ERK | |
ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM). | |||
T6818 | DEL-22379 | DEL22379 | Apoptosis , ERK |
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ~0.5 μM. | |||
T1956 | FR 180204 | FR180204 | Apoptosis , ERK |
FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2. | |||
T4091 | Temuterkib | LY3214996 | ERK |
Temuterkib (LY3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. | |||
T10429 | Tizaterkib | AZD-0364 | ERK |
Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor. | |||
T6511 | Ravoxertinib | GDC-0994 | ERK |
Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM). | |||
T36674 | DMU-212 | Apoptosis , ERK | |
DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2... | |||
T11224 | Rineterkib | ERK-IN-1 | ERK , Raf |
T6948 | Pluripotin | SC1 | ERK , Raf , S6 Kinase |
Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. | |||
T1843 | XMD8-92 | ERK , BMI-1 , Epigenetic Reader Domain | |
XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM). | |||
T21295 | BIX02189 | BIX 02189 | ERK , MEK |
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM). | |||
T12069 | MK-8353 | SCH900353 | ERK |
T2029 | Bohemine | ERK , CDK | |
Bohemine is a cyclin-dependent kinase inhibitor. | |||
T1842 | XMD17-109 | XMD17 109,ERK5-IN-1 | ERK |
XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells). | |||
T4496 | LM22B-10 | LM22B10 | ERK , Trk receptor , Akt |
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo. | |||
T7506 | Yoda 1 | Piezo Channel | |
Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively) | |||
T9141 | ERK-IN-3 | ASN007 free base | ERK |
ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations. | |||
T5364 | TBHQ | tert-Butylhydroquinone | Apoptosis , ERK , Others , Ferroptosis , Nrf2 , Autophagy |
TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2. | |||
T2623 | PD98059 | PD 98059 | ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy |
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy. | |||
T8472 | ERK1/2 inhibitor 2 | ASTX-029,ASTX029 | ERK |
ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity. | |||
T3166 | VX-11e | Vertex-11e,VTX-11e,TCS ERK 11e | ERK , GSK-3 , FLT , CDK , Aurora Kinase |
VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent. | |||
T7005 | Ulixertinib | BVD-523,VRT752271 | ERK |
Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2. | |||
T27242 | EF24 | EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone | ERK , MEK , Caspase |
EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral ... | |||
T1144L | Lidocaine Hydrochloride hydrate | EGFR , Sodium Channel | |
Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property. | |||
T4092 | AG126 | Tyrphostin AG126,AG 126 | ERK , COX |
AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expres... | |||
T2171 | SEW2871 | SEW2871 | S1P Receptor , LPL Receptor |
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an... | |||
T0468 | Lidocaine | Lignocaine,Alphacaine,Xylocaine | Apoptosis , ERK , NF-κB , MEK , Sodium Channel , Histamine Receptor |
Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammat... | |||
T9776 | TRPM4 inhibitor 8 | TRP/TRPV Channel | |
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion. | |||
T0304 | Methylthiouracil | NSC-193526,NSC-9378,MTU | ERK , Antiviral , TNF , NF-κB , Interleukin |
Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism. | |||
T2036 | 6-OAU | GTPL5846 | GPR |
6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. | |||
T1144 | Lidocaine hydrochloride | Lidocaine HCL,Lignocaine hydrochloride,Xyloneural,Lidothesin | Apoptosis , ERK , NF-κB , MEK , Sodium Channel |
Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its ... | |||
T6993 | Tauroursodeoxycholate sodium | Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,Sodium Tauroursodeoxycholate (TUDC) | Apoptosis , ERK , Caspase |
Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis. | |||
T36672 | CAY10561 | ||
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are con... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T6S0655 | Corynoxeine | ERK | |
1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and restenosis after angioplasty. | |||
TN2346 | Mogrol | ERK , AMPK , STAT | |
Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling. | |||
T3856 | Tenuifoliside A | ERK , Others | |
Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways. | |||
T3857 | Magnolin | (+)-Magnolin | ERK |
Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects. | |||
T3844 | Deltonin | ERK , Others , Akt , Endogenous Metabolite | |
Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), and human MDA-MB-231 cells (IC50: 1.58 μM). | |||
TN3967 | Epieriocalyxin A | ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK | |
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future. | |||
T6947 | Piperlongumine | PPLGM,Piplartine | Apoptosis , ERK , Ferroptosis , Reactive Oxygen Species , ROS , Antibacterial , Autophagy |
Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS). | |||
TN1410 | Asperulosidic acid | ASPA | ERK , NF-κB |
Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-a... | |||
TL0016 | Sulforaphene | Apoptosis , ERK , EGFR , NF-κB | |
Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EG... | |||
TN1721 | Gypenoside L | ERK , p38 MAPK , Calcium Channel , NF-κB , ROS | |
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a... | |||
T3876 | Loureirin B | PAI-1 , ERK , Potassium Channel , JNK | |
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathw... | |||
T6S0619 | Pachymic acid | 3-O-Acetyltumulosic acid | ERK , Akt |
Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways. | |||
T5727 | CAFESTOL | ERK , NF-κB , COX , PGE Synthase | |
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production... | |||
TMS2181 | Trans-Zeatin | (E)-Zeatin | ERK , MEK , Endogenous Metabolite |
trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. | |||
T3001 | Honokiol | NSC 293100 | ERK , HCV Protease , MEK , Akt , Autophagy |
Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2. | |||
T5S0761 | Nitidine chloride | Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite | |
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id... | |||
T2973 | Astragaloside IV | AST-IV,AS-IV | MMP , ERK , Estrogen/progestogen Receptor , JNK |
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel... | |||
T13265 | Urolithin B | ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK | |
Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs. Urolithin B inhibits NF-κB activit... | |||
TN2354 | Methylnissolin | 3-Hydroxy-9,10-dimethoxyptercarpan | ERK , PDGFR |
Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects. | |||
T6S0117 | Avicularin | Fenicularin | ERK |
Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX... | |||
T17143 | Toyocamycin | Vengicide | Apoptosis , Others , IRE1 , Antibiotic , Antifungal |
Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis. | |||
T2532 | Tauroursodeoxycholate | Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA | Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite |
Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode... | |||
TCS2170 | 2,5-Dihydroxyacetophenone | Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP | ERK , NF-κB , Tyrosinase |
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK... | |||
T3892 | Isoacteoside | Isoverbascoside | NF-κB |
Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B p... | |||
T6S1597 | Mulberroside A | TNF , Tyrosinase , Interleukin | |
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-04569 | MEK1 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin... | |||
TMPY-04756 | MEK1 Protein, Mouse, Recombinant | Mouse | Baculovirus-Insect Cells |
MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin... | |||
TMPY-04378 | MAPKAPK3 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases ... | |||
TMPY-04571 | ERK2 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, diffe... | |||
TMPY-04539 | ERK2 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, diffe... |